Ryrie addresses the means of regeneration:
“The Scriptures clearly teach that regeneration is the act of God. Direct statements show this (John 1:13) as well as statements that link regeneration to spiritual resurrection - an act which God alone can accomplish (John 5:21-24; Romans 6:14; 2 Corinthians 5:17). . . . it is the work of the Holy Spirit of God (John 3:3-7; Titus 3:5). . . . the means of regeneration is the Spirit’s effecting the new birth in those who believe in Christ.”
As I have shared in my books and blogs the sin sacrifice of Jesus Christ provided for the restoration of a permanent indwelling of the human spirit by the Holy Spirit whom Jesus sent upon His resurrection. Recipients of this blessing are repentant believers. I have addressed the dualist interaction that characterizes this two-way communion through God’s created synaptic networks in our time. In this connection the Bible and neuroscience, properly interpreted, are in concordance. Ryrie states further, “. . . the actual event of being born again happens instantaneously. . . . people do not birth themselves, but that they are birthed by Someone Else, the Holy Spirit.”